Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies
نویسندگان
چکیده
منابع مشابه
Coadaptation of prenatal and postnatal maternal effects.
In a wide variety of species, a female's age of first reproduction influences offspring size and survival, suggesting that there exists an optimal timing of reproduction. Mothers in many species also influence offspring size and survival after birth through variation in parental care. We experimentally separated these effects in the burying beetle Nicrophorus vespilloides to test for coadaptati...
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Fetal DNA is present in the plasma of pregnant women. Massively parallel sequencing of maternal plasma DNA has been used to detect fetal trisomies 21, 18, 13 and selected sex chromosomal aneuploidies noninvasively. Case reports describing the detection of fetal microdeletions from maternal plasma using massively parallel sequencing have been reported. However, these previous reports were either...
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Guidelines for developmental toxicity studies require that the highest dose(s) should induce some signs of maternal toxicity. However, the interpretation of the results is often difficult when developmentally toxic effects are recorded only at maternotoxic doses, as it is impossible to ascertain whether the developmental effects are maternally mediated or not. In order to avoid this source of m...
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We have known for some time that normal growth is not simply a uniform process of getting larger proportionately in all tissues (Scammon, 1930). The reproductive system, for example, achieves almost all of its growth during the few years of adolescence. The brain achieves a significant amount of its growth prenatally and reaches 60% of its total mass by 2 years of age in the human. Such mass me...
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The discovery of the presence of fetal DNA in maternal plasma has provided a new approach for non-invasive prenatal diagnosis. At present, the prenatal diagnosis of thalassaemia relies on invasive methods. We designed allele-specific primers and a fluorescent probe for detection of the codon 41/42 (–CTTT) mutation in the globin gene from maternal plasma by real-time PCR. The specificity and sen...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2019
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2018.10.032